If `cplex` and `docplex` are installed in a virtual environment (using the builtin `venv` module), `docplex config --upgrade` fails here: https://github.com/IBMDecisionOptimization/docplex/blob/master/docplex/util/cli.py#L55-L74 Replacing ```python out = subprocess.run(["python", "-c", sub_program], capture_output=True) ``` by ```python out = subprocess.run([sys.executable, "-c", sub_program], capture_output=True) ``` ...seems to fix the issue.