diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 0f5283438e5..8f1de145244 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -105,7 +105,7 @@ jobs:
     strategy:
       matrix:
         platform: [amd64, arm64]
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -132,7 +132,7 @@ jobs:
     strategy:
       matrix:
         platform: [amd64, arm64]
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -235,7 +235,7 @@ jobs:
       matrix:
         platform: [amd64, arm64]
         python_version: ['3.11', '3.13']
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/python_wheels.yml
     secrets:
@@ -256,7 +256,7 @@ jobs:
     with:
       cudaq_version: ${{ needs.python_wheels.outputs.cudaq_version }}
       python_versions: "['3.11', '3.13']"
-      cuda_versions: "['', '11.8', '12.0']"
+      cuda_versions: "['', '12.6']"
       wheel_artifacts: 'pycudaq-*'
 
   binaries:
@@ -265,7 +265,7 @@ jobs:
     strategy:
       matrix:
         platform: [amd64, arm64]
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/prebuilt_binaries.yml
     secrets:
diff --git a/.github/workflows/config/validation_config.json b/.github/workflows/config/validation_config.json
index 38d5d52c252..a5e32ff862f 100644
--- a/.github/workflows/config/validation_config.json
+++ b/.github/workflows/config/validation_config.json
@@ -1,14 +1,6 @@
 {
     "python":
     [
-        {
-            "version": "3.10",
-            "operating_systems": 
-            [
-                "ubuntu:22.04",
-                "fedora:42"
-            ]
-        },
         {
             "version": "3.11",
             "operating_systems": 
@@ -55,7 +47,7 @@
             "ubuntu:22.04": 
             {
                 "libcdev_package": "libc6-dev",
-                "cudart_version": "12.0",
+                "cudart_version": "12.6",
                 "cuda_distribution": "ubuntu2204"
             },
             "debian:12": 
@@ -67,13 +59,13 @@
             "redhat/ubi9:9.6":
             {
                 "libcdev_package": "glibc-devel",
-                "cudart_version": "12.0",
+                "cudart_version": "12.6",
                 "cuda_distribution": "rhel9"
             },
             "opensuse/leap:15.5": 
             {
                 "libcdev_package": "glibc-devel",
-                "cudart_version": "12.0",
+                "cudart_version": "12.6",
                 "cuda_distribution": "opensuse15"
             },
             "fedora:42":
@@ -129,13 +121,13 @@
             "ubuntu:22.04": 
             {
                 "libcdev_package": "libc6-dev",
-                "cudart_version": "12.0",
+                "cudart_version": "12.6",
                 "cuda_distribution": "ubuntu2204"
             },
             "redhat/ubi9:9.6":
             {
                 "libcdev_package": "glibc-devel",
-                "cudart_version": "12.0",
+                "cudart_version": "12.6",
                 "cuda_distribution": "rhel9"
             }
         },
diff --git a/.github/workflows/create_cache_command.yml b/.github/workflows/create_cache_command.yml
index 5f9d158f0a9..c5baed43283 100644
--- a/.github/workflows/create_cache_command.yml
+++ b/.github/workflows/create_cache_command.yml
@@ -112,7 +112,7 @@ jobs:
     strategy:
       matrix:
         platform: [amd64, arm64]
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -141,7 +141,7 @@ jobs:
     strategy:
       matrix:
         platform: [amd64, arm64]
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
diff --git a/.github/workflows/deployments.yml b/.github/workflows/deployments.yml
index 7fd9eba859b..2db72b2ea4c 100644
--- a/.github/workflows/deployments.yml
+++ b/.github/workflows/deployments.yml
@@ -205,7 +205,7 @@ jobs:
         # There are currently no multi-platform manylinux images available.
         # See https://github.com/pypa/manylinux/issues/1306.
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -237,7 +237,7 @@ jobs:
     strategy:
       matrix:
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -268,7 +268,7 @@ jobs:
     strategy:
       matrix:
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -354,7 +354,7 @@ jobs:
     strategy:
       matrix:
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/dev_environment.yml
     secrets:
@@ -402,7 +402,7 @@ jobs:
     strategy:
       matrix:
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/docker_images.yml
     secrets:
@@ -443,7 +443,7 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        cuda: ["11.8", "12.0"]
+        cuda: ["12.6"]
 
     environment: ghcr-deployment
 
@@ -666,7 +666,7 @@ jobs:
           STITCHED_JSON='${{ needs.aggregate_stitched_images.outputs.json }}'
           echo "$STITCHED_JSON" | jq .
 
-          for cuda in 11.8 12.0; do
+          for cuda in 12.6; do
             cuda_major="${cuda%%.*}"
             artifact_name="image_cu${cuda_major}_publishing"            
             info_file="$artifact_name.txt"
@@ -718,8 +718,8 @@ jobs:
     strategy:
       matrix:
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        python_version: ['3.10', '3.11', '3.12', '3.13']
-        cuda_version: ["11.8", "12.0"]
+        python_version: ['3.11', '3.12', '3.13']
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/python_wheels.yml
     secrets:
@@ -738,7 +738,7 @@ jobs:
     strategy:
       matrix:
         platform: ${{ fromJson(needs.metadata.outputs.platforms).ids }}
-        cuda_version: ["11.8", "12.0"]
+        cuda_version: ["12.6"]
       fail-fast: false
     uses: ./.github/workflows/prebuilt_binaries.yml
     secrets:
diff --git a/.github/workflows/docker_images.yml b/.github/workflows/docker_images.yml
index 8d66855516f..f2d8a2c7e19 100644
--- a/.github/workflows/docker_images.yml
+++ b/.github/workflows/docker_images.yml
@@ -842,7 +842,7 @@ jobs:
           docker cp docs/notebook_validation.py cuda-quantum:"/home/cudaq/notebook_validation.py"
           # In containers without GPU support, UCX does not work properly since it is configured to work with GPU-support.
           # Hence, don't enforce UCX when running these tests.
-          docker exec cuda-quantum bash -c "python3 -m pip install pandas scipy pandas seaborn 'h5py<3.11' contfrac"
+          docker exec cuda-quantum bash -c "python3 -m pip install pandas scipy pandas seaborn h5py contfrac"
           (docker exec cuda-quantum bash -c "unset OMPI_MCA_pml && set -o pipefail && bash validate_container.sh | tee /tmp/validation.out") && passed=true || passed=false
           docker cp cuda-quantum:"/tmp/validation.out" /tmp/validation.out
           docker stop cuda-quantum
diff --git a/.github/workflows/integration_tests.yml b/.github/workflows/integration_tests.yml
index 0ee6ac2ebf7..b88f2c3a6ed 100644
--- a/.github/workflows/integration_tests.yml
+++ b/.github/workflows/integration_tests.yml
@@ -58,7 +58,6 @@ on:
         required: true
         description: 'Python version to run wheel test'
         options:
-        - '3.10'
         - '3.11'
         - '3.12'
         - '3.13'
@@ -72,7 +71,7 @@ env:
   NVQC_FUNCTION_ID: 3bfa0342-7d2a-4f1b-8e81-b6608d28ca7d
   # <Backend>:<GPU Type>:<Instance Type>:<Min Instances>:<Max Instances>
   NGC_NVQC_DEPLOYMENT_SPEC: GFN:L40S:gl40s_1.br25_2xlarge:1:1
-  python_version: '3.10'
+  python_version: '3.12'
 
 jobs:
   # We need this job purely to choose the container image values because the
diff --git a/.github/workflows/nvqc_regression_tests.yml b/.github/workflows/nvqc_regression_tests.yml
index dd0522cc4c7..055eeb2e723 100644
--- a/.github/workflows/nvqc_regression_tests.yml
+++ b/.github/workflows/nvqc_regression_tests.yml
@@ -26,7 +26,6 @@ on:
         required: true
         description: 'Python version to run wheel test'
         options:
-        - '3.10'
         - '3.11'
         - '3.12'
         - '3.13'
@@ -35,7 +34,7 @@ on:
     - cron: 0 3 * * *
 
 env:
-  python_version: '3.10'
+  python_version: '3.12'
 
 jobs:
   # We need this job purely to choose the container image values because the
diff --git a/.github/workflows/publishing.yml b/.github/workflows/publishing.yml
index 0edaa6d5967..bf7476fdd6c 100644
--- a/.github/workflows/publishing.yml
+++ b/.github/workflows/publishing.yml
@@ -650,7 +650,7 @@ jobs:
     strategy:
       matrix:
         info_file: ${{ fromJson(needs.assets.outputs.python_wheels).info_files }}
-        python_version: ['3.10', '3.11', '3.12', '3.13']
+        python_version: ['3.11', '3.12', '3.13']
       fail-fast: false
 
     runs-on: ${{ (contains(matrix.info_file, 'arm') && 'linux-arm64-cpu8') || 'linux-amd64-cpu8' }}
@@ -733,10 +733,10 @@ jobs:
       - name: Set retention days
         id: set_retention_days
         run: |
-          # Save the x86_64-py3.10-wheels for longer because our some of our
+          # Save the x86_64-py3.12-wheels for longer because our some of our
           # nightly jobs rely on them being present, even if we haven't done a
           # fresh publishing in the last 24 hours.
-          if [ "${{ steps.release_info.outputs.platform_arch }}" == "x86_64" ] && [ "${{ matrix.python_version }}" == "3.10" ]; then
+          if [ "${{ steps.release_info.outputs.platform_arch }}" == "x86_64" ] && [ "${{ matrix.python_version }}" == "3.12" ]; then
             echo "retention_days=7" >> $GITHUB_OUTPUT
           else
             echo "retention_days=1" >> $GITHUB_OUTPUT
@@ -782,8 +782,8 @@ jobs:
     uses: ./.github/workflows/python_metapackages.yml
     with:
       cudaq_version: ${{ needs.assets.outputs.cudaq_version }}
-      python_versions: "['3.10', '3.11', '3.12', '3.13']"
-      cuda_versions: "['', '11.8', '12.0']"
+      python_versions: "['3.11', '3.12', '3.13']"
+      cuda_versions: "['', '12.6']"
       wheel_artifacts: '*-wheels'
       github_commit: ${{ inputs.github_commit || needs.assets.outputs.github_commit }}
 
@@ -925,7 +925,7 @@ jobs:
     strategy:
       matrix:
         os_image: ['redhat/ubi8:8.10', 'ubuntu:22.04']
-        cuda_version: ['11.8', '12.0']
+        cuda_version: ['12.6']
       fail-fast: false
 
     container:
@@ -1203,7 +1203,7 @@ jobs:
           source validate_pycudaq.sh \
             -v ${{ needs.assets.outputs.cudaq_version }} \
             -i /tmp/packages -f /tmp \
-            -c ${{ matrix.cuda_version }} -p 3.10
+            -c ${{ matrix.cuda_version }} -p 3.12
           set -e # Re-enable exit code error checking
 
           expected_dependency=cuda-quantum-cu$(echo ${{ matrix.cuda_version }} | cut -d . -f1)
diff --git a/.github/workflows/python_metapackages.yml b/.github/workflows/python_metapackages.yml
index 15ed0eeb7dd..87af87cf80f 100644
--- a/.github/workflows/python_metapackages.yml
+++ b/.github/workflows/python_metapackages.yml
@@ -8,11 +8,11 @@ on:
       python_versions:
         required: true
         type: string
-        description: Json array of the Python versions to test the packages with (e.g. ['3.10', '3.12']).
+        description: Json array of the Python versions to test the packages with (e.g. ['3.11', '3.12']).
       cuda_versions:
         required: true
         type: string
-        description: Json array of the CUDA versions to test the packages with (e.g. ['11.8', '12.0']).
+        description: Json array of the CUDA versions to test the packages with (e.g. ['12.6']).
       wheel_artifacts:
         required: true
         type: string
diff --git a/docker/build/devdeps.Dockerfile b/docker/build/devdeps.Dockerfile
index 93b1318745b..5a9e0205049 100644
--- a/docker/build/devdeps.Dockerfile
+++ b/docker/build/devdeps.Dockerfile
@@ -23,7 +23,7 @@
 # then the toolchain will be built from source.
 
 # [Operating System]
-ARG base_image=ubuntu:22.04
+ARG base_image=ubuntu:24.04
 
 # [CUDA-Q Dependencies]
 FROM ${base_image} AS prereqs
@@ -51,12 +51,14 @@ ENV ZLIB_INSTALL_PREFIX=/usr/local/zlib
 ENV OPENSSL_INSTALL_PREFIX=/usr/local/openssl
 ENV CURL_INSTALL_PREFIX=/usr/local/curl
 ENV AWS_INSTALL_PREFIX=/usr/local/aws
+# TODO: eliminate the need for this
+ENV PIP_BREAK_SYSTEM_PACKAGES=1
 
 ## [Build Dependencies]
 RUN apt-get update && apt-get install -y --no-install-recommends \
         wget git unzip \
         python3-dev python3-pip && \
-    python3 -m pip install --no-cache-dir numpy && \
+    python3 -m pip install --no-cache-dir numpy --break-system-packages && \
     apt-get autoremove -y --purge && apt-get clean && rm -rf /var/lib/apt/lists/*
 ADD scripts/install_toolchain.sh /cuda-quantum/scripts/install_toolchain.sh
 RUN source /cuda-quantum/scripts/install_toolchain.sh \
@@ -151,23 +153,21 @@ RUN apt-get update && apt-get install --no-install-recommends -y wget ca-certifi
     && apt-get remove -y wget ca-certificates \
     && apt-get autoremove -y --purge && apt-get clean && rm -rf /var/lib/apt/lists/*
 ENV PATH="${PATH}:/usr/local/cmake-3.28/bin"
-# We must use h5py<3.11 because 3.11 doesn't include aarch64 Linux wheels.
-# https://github.com/h5py/h5py/issues/2408
 RUN apt-get update && apt-get install -y --no-install-recommends \
         git gdb ninja-build file lldb \
         python3 python3-pip libpython3-dev \
-    && python3 -m pip install --no-cache-dir \
+    && python3 -m pip install --no-cache-dir --break-system-packages \
         lit==18.1.4 pytest==8.2.0 numpy==1.26.4 requests==2.31.0 \
         fastapi==0.111.0 uvicorn==0.29.0 pydantic==2.7.1 llvmlite==0.42.0 \
         pyspelling==2.10 pymdown-extensions==10.8.1 yapf \
-        scipy==1.10.1 openfermionpyscf==0.5 'h5py<3.11' \
+        scipy==1.11.4 openfermionpyscf==0.5 h5py==3.12.1 \
     && apt-get autoremove -y --purge && apt-get clean && rm -rf /var/lib/apt/lists/*
 
 # Install additional tools for CUDA-Q documentation generation.
 COPY --from=prereqs /usr/local/bin/doxygen /usr/local/bin/doxygen
 ENV PATH="${PATH}:/usr/local/bin"
 RUN apt-get update && apt-get install -y --no-install-recommends python3 python3-pip pandoc aspell aspell-en \
-    && python3 -m pip install --no-cache-dir \
+    && python3 -m pip install --no-cache-dir --break-system-packages \
         ipython==8.15.0 pandoc==2.3 sphinx==5.3.0 sphinx_rtd_theme==1.2.0 sphinx-reredirects==0.1.2 \
         sphinx-copybutton==0.5.2 sphinx_inline_tabs==2023.4.21 enum-tools[sphinx] breathe==4.34.0 \
         nbsphinx==0.9.2 sphinx_gallery==0.13.0 myst-parser==1.0.0 ipykernel==6.29.4 notebook==7.3.2 \
diff --git a/docker/build/devdeps.ext.Dockerfile b/docker/build/devdeps.ext.Dockerfile
index 254c61be3e4..ea8c0b86508 100644
--- a/docker/build/devdeps.ext.Dockerfile
+++ b/docker/build/devdeps.ext.Dockerfile
@@ -16,7 +16,7 @@
 # Must be built from the repo root with:
 #   docker build -t ghcr.io/nvidia/cuda-quantum-devdeps:ext -f docker/build/devdeps.ext.Dockerfile .
 
-ARG cuda_version=11.8
+ARG cuda_version=12.6
 ARG base_image=ghcr.io/nvidia/cuda-quantum-devdeps:gcc11-main
 ARG ompidev_image=ghcr.io/nvidia/cuda-quantum-devdeps:cu12-ompi-main
 FROM $ompidev_image AS ompibuild
@@ -163,25 +163,27 @@ ENV CUDA_HOME="$CUDA_INSTALL_PREFIX"
 ENV CUDA_ROOT="$CUDA_INSTALL_PREFIX"
 ENV CUDA_PATH="$CUDA_INSTALL_PREFIX"
 ENV PATH="${CUDA_INSTALL_PREFIX}/lib64/:${CUDA_INSTALL_PREFIX}/bin:${PATH}"
+# TODO: Eliminate the need for this
+ENV PIP_BREAK_SYSTEM_PACKAGES=1
 
 # Install cuQuantum dependencies, including cuTensor.
 # Install cupy version 13.4.1
 RUN apt-get update && apt-get install -y --no-install-recommends \
         python3 python3-pip && \
     apt-get autoremove -y && apt-get clean && rm -rf /var/lib/apt/lists/* && \
-    python3 -m pip install cupy-cuda$(echo $CUDA_VERSION | cut -d . -f1)x==13.4.1 cuquantum-cu$(echo $CUDA_VERSION | cut -d . -f1)~=25.06 && \
-    if [ "$(python3 --version | grep -o [0-9\.]* | cut -d . -f -2)" != "3.10" ]; then \
-        echo "expecting Python version 3.10"; \
+    python3 -m pip install --break-system-packages cupy-cuda$(echo $CUDA_VERSION | cut -d . -f1)x==13.4.1 cuquantum-cu$(echo $CUDA_VERSION | cut -d . -f1)~=25.06 && \
+    if [ "$(python3 --version | grep -o [0-9\.]* | cut -d . -f -2)" != "3.12" ]; then \
+        echo "expecting Python version 3.12"; \
     fi
 
-ARG CUQUANTUM_INSTALL_PREFIX=/usr/local/lib/python3.10/dist-packages/cuquantum
+ARG CUQUANTUM_INSTALL_PREFIX=/usr/local/lib/python3.12/dist-packages/cuquantum
 ENV CUQUANTUM_INSTALL_PREFIX="$CUQUANTUM_INSTALL_PREFIX"
 ENV CUQUANTUM_ROOT="$CUQUANTUM_INSTALL_PREFIX"
 ENV CUQUANTUM_PATH="$CUQUANTUM_INSTALL_PREFIX"
 ENV LD_LIBRARY_PATH="$CUQUANTUM_INSTALL_PREFIX/lib:$LD_LIBRARY_PATH"
 ENV CPATH="$CUQUANTUM_INSTALL_PREFIX/include:$CPATH"
 
-ARG CUTENSOR_INSTALL_PREFIX=/usr/local/lib/python3.10/dist-packages/cutensor
+ARG CUTENSOR_INSTALL_PREFIX=/usr/local/lib/python3.12/dist-packages/cutensor
 ENV CUTENSOR_INSTALL_PREFIX="$CUTENSOR_INSTALL_PREFIX"
 ENV CUTENSOR_ROOT="$CUTENSOR_INSTALL_PREFIX"
 ENV LD_LIBRARY_PATH="$CUTENSOR_INSTALL_PREFIX/lib:$LD_LIBRARY_PATH"
diff --git a/docker/build/devdeps.ompi.Dockerfile b/docker/build/devdeps.ompi.Dockerfile
index 3a408ee7cdf..17be70db6d6 100644
--- a/docker/build/devdeps.ompi.Dockerfile
+++ b/docker/build/devdeps.ompi.Dockerfile
@@ -15,8 +15,8 @@
 # Must be built from the repo root with:
 #   docker build -t ghcr.io/nvidia/cuda-quantum-devdeps:ompi -f docker/build/devdeps.ompi.Dockerfile .
 
-ARG cuda_version=12.0
-FROM nvidia/cuda:${cuda_version}.0-devel-ubuntu22.04
+ARG cuda_version=12.6
+FROM nvidia/cuda:${cuda_version}.0-devel-ubuntu24.04
 SHELL ["/bin/bash", "-c"]
 ARG DEBIAN_FRONTEND=noninteractive
 ARG cuda_version
@@ -26,6 +26,7 @@ ARG TARGETARCH
 ENV CUDA_INSTALL_PREFIX=/usr/local/cuda-${CUDA_VERSION}
 ENV COMMON_COMPILER_FLAGS="-march=x86-64-v3 -mtune=generic -O2 -pipe"
 ENV COMMON_COMPILER_FLAGS_ARM="-march=armv8-a -mtune=generic -O2 -pipe"
+ENV PIP_BREAK_SYSTEM_PACKAGES=1
 
 # 1 - Install basic tools needed for the builds
 
@@ -33,7 +34,7 @@ RUN apt-get update && apt-get install -y --no-install-recommends \
         gcc g++ gfortran python3 python3-pip \
         libcurl4-openssl-dev libssl-dev liblapack-dev libpython3-dev \
         bzip2 make sudo vim curl git wget \
-    && pip install --no-cache-dir numpy \
+    && pip install --no-cache-dir numpy --break-system-packages \
     && apt-get autoremove -y --purge && apt-get clean && rm -rf /var/lib/apt/lists/* 
 
 # 2 - Install SLURM PMI2 version 21.08.8
@@ -80,12 +81,12 @@ RUN apt-get update -y && apt-get install -y --no-install-recommends \
 ENV CPATH="$GDRCOPY_INSTALL_PREFIX/include:$CPATH"
 ENV LIBRARY_PATH="$GDRCOPY_INSTALL_PREFIX/lib64:$LIBRARY_PATH"
 
-# 5 - Install UCX version v1.13.1
+# 5 - Install UCX version v1.16.0
 
 ENV UCX_INSTALL_PREFIX=/usr/local/ucx
 RUN mkdir -p /var/tmp && cd /var/tmp \
     && git clone https://github.com/openucx/ucx.git ucx && cd /var/tmp/ucx \
-    && git checkout v1.13.1 \
+    && git checkout v1.16.0 \
     && ./autogen.sh \
     && export common_flags=$([ "$TARGETARCH" == "arm64" ] && echo "$COMMON_COMPILER_FLAGS_ARM" || echo "$COMMON_COMPILER_FLAGS") \
     &&  CC=gcc CFLAGS="$common_flags" \
diff --git a/python/metapackages/pyproject.toml b/python/metapackages/pyproject.toml
index a6c2c4d1f33..92ef07dc263 100644
--- a/python/metapackages/pyproject.toml
+++ b/python/metapackages/pyproject.toml
@@ -37,10 +37,8 @@ Documentation = "https://nvidia.github.io/cuda-quantum"
 Repository = "https://github.com/NVIDIA/cuda-quantum"
 Releases = "https://nvidia.github.io/cuda-quantum/latest/releases.html"
 
-# We must use h5py<3.11 because 3.11 doesn't include aarch64 Linux wheels.
-# https://github.com/h5py/h5py/issues/2408
 [project.optional-dependencies]
-chemistry = [ "scipy==1.10.1", "openfermionpyscf==0.5", "h5py<3.11"  ]
+chemistry = [ "scipy==1.10.1", "openfermionpyscf==0.5", "h5py==3.12.1"  ]
 visualization = [ "qutip<5" , "matplotlib>=3.5" ]
 
 [build-system]