diff --git a/monai/inferers/inferer.py b/monai/inferers/inferer.py
index bfb2756ebe..3687119baa 100644
--- a/monai/inferers/inferer.py
+++ b/monai/inferers/inferer.py
@@ -839,6 +839,7 @@ def sample(
         mode: str = "crossattn",
         verbose: bool = True,
         seg: torch.Tensor | None = None,
+        cfg: float | None = None,
     ) -> torch.Tensor | tuple[torch.Tensor, list[torch.Tensor]]:
         """
         Args:
@@ -851,6 +852,7 @@ def sample(
             mode: Conditioning mode for the network.
             verbose: if true, prints the progression bar of the sampling process.
             seg: if diffusion model is instance of SPADEDiffusionModel, segmentation must be provided.
+            cfg: classifier-free-guidance scale, which indicates the level of strengthening on the conditioning.
         """
         if mode not in ["crossattn", "concat"]:
             raise NotImplementedError(f"{mode} condition is not supported")
@@ -877,15 +879,31 @@ def sample(
                 if isinstance(diffusion_model, SPADEDiffusionModelUNet)
                 else diffusion_model
             )
-            if mode == "concat" and conditioning is not None:
-                model_input = torch.cat([image, conditioning], dim=1)
+            if (
+                cfg is not None
+            ):  # if classifier-free guidance is used, a conditioned and unconditioned bit is generated.
+                model_input = torch.cat([image] * 2, dim=0)
+                if conditioning is not None:
+                    uncondition = torch.ones_like(conditioning)
+                    uncondition.fill_(-1)
+                    conditioning_input = torch.cat([uncondition, conditioning], dim=0)
+                else:
+                    conditioning_input = None
+            else:
+                model_input = image
+                conditioning_input = conditioning
+            if mode == "concat" and conditioning_input is not None:
+                model_input = torch.cat([model_input, conditioning_input], dim=1)
                 model_output = diffusion_model(
                     model_input, timesteps=torch.Tensor((t,)).to(input_noise.device), context=None
                 )
             else:
                 model_output = diffusion_model(
-                    image, timesteps=torch.Tensor((t,)).to(input_noise.device), context=conditioning
+                    model_input, timesteps=torch.Tensor((t,)).to(input_noise.device), context=conditioning_input
                 )
+            if cfg is not None:
+                model_output_uncond, model_output_cond = model_output.chunk(2)
+                model_output = model_output_uncond + cfg * (model_output_cond - model_output_uncond)
 
             # 2. compute previous image: x_t -> x_t-1
             if not isinstance(scheduler, RFlowScheduler):
@@ -1166,6 +1184,7 @@ def sample(  # type: ignore[override]
         mode: str = "crossattn",
         verbose: bool = True,
         seg: torch.Tensor | None = None,
+        cfg: float | None = None,
     ) -> torch.Tensor | tuple[torch.Tensor, list[torch.Tensor]]:
         """
         Args:
@@ -1180,6 +1199,7 @@ def sample(  # type: ignore[override]
             verbose: if true, prints the progression bar of the sampling process.
             seg: if diffusion model is instance of SPADEDiffusionModel, or autoencoder_model
              is instance of SPADEAutoencoderKL, segmentation must be provided.
+            cfg: classifier-free-guidance scale, which indicates the level of strengthening on the conditioning.
         """
 
         if (
@@ -1203,6 +1223,7 @@ def sample(  # type: ignore[override]
             mode=mode,
             verbose=verbose,
             seg=seg,
+            cfg=cfg,
         )
 
         if save_intermediates:
@@ -1381,6 +1402,7 @@ def sample(  # type: ignore[override]
         mode: str = "crossattn",
         verbose: bool = True,
         seg: torch.Tensor | None = None,
+        cfg: float | None = None,
     ) -> torch.Tensor | tuple[torch.Tensor, list[torch.Tensor]]:
         """
         Args:
@@ -1395,6 +1417,7 @@ def sample(  # type: ignore[override]
             mode: Conditioning mode for the network.
             verbose: if true, prints the progression bar of the sampling process.
             seg: if diffusion model is instance of SPADEDiffusionModel, segmentation must be provided.
+                        cfg: classifier-free-guidance scale, which indicates the level of strengthening on the conditioning.
         """
         if mode not in ["crossattn", "concat"]:
             raise NotImplementedError(f"{mode} condition is not supported")
@@ -1413,14 +1436,31 @@ def sample(  # type: ignore[override]
             progress_bar = iter(zip(scheduler.timesteps, all_next_timesteps))
         intermediates = []
 
+        if cfg is not None:
+            cn_cond = torch.cat([cn_cond] * 2, dim=0)
+
         for t, next_t in progress_bar:
+            # Controlnet prediction
+            if cfg is not None:
+                model_input = torch.cat([image] * 2, dim=0)
+                if conditioning is not None:
+                    uncondition = torch.ones_like(conditioning)
+                    uncondition.fill_(-1)
+                    conditioning_input = torch.cat([uncondition, conditioning], dim=0)
+                else:
+                    conditioning_input = None
+            else:
+                model_input = image
+                conditioning_input = conditioning
+
+            # Diffusion model prediction
             diffuse = diffusion_model
             if isinstance(diffusion_model, SPADEDiffusionModelUNet):
                 diffuse = partial(diffusion_model, seg=seg)
 
-            if mode == "concat" and conditioning is not None:
+            if mode == "concat" and conditioning_input is not None:
                 # 1. Conditioning
-                model_input = torch.cat([image, conditioning], dim=1)
+                model_input = torch.cat([model_input, conditioning_input], dim=1)
                 # 2. ControlNet forward
                 down_block_res_samples, mid_block_res_sample = controlnet(
                     x=model_input,
@@ -1437,20 +1477,28 @@ def sample(  # type: ignore[override]
                     mid_block_additional_residual=mid_block_res_sample,
                 )
             else:
+                # 1. Controlnet forward
                 down_block_res_samples, mid_block_res_sample = controlnet(
-                    x=image,
+                    x=model_input,
                     timesteps=torch.Tensor((t,)).to(input_noise.device),
                     controlnet_cond=cn_cond,
-                    context=conditioning,
+                    context=conditioning_input,
                 )
+                # 2. predict noise model_output
                 model_output = diffuse(
-                    image,
+                    model_input,
                     timesteps=torch.Tensor((t,)).to(input_noise.device),
-                    context=conditioning,
+                    context=conditioning_input,
                     down_block_additional_residuals=down_block_res_samples,
                     mid_block_additional_residual=mid_block_res_sample,
                 )
 
+            # If classifier-free guidance isn't None, we split and compute the weighting between
+            # conditioned and unconditioned output.
+            if cfg is not None:
+                model_output_uncond, model_output_cond = model_output.chunk(2)
+                model_output = model_output_uncond + cfg * (model_output_cond - model_output_uncond)
+
             # 3. compute previous image: x_t -> x_t-1
             if not isinstance(scheduler, RFlowScheduler):
                 image, _ = scheduler.step(model_output, t, image)  # type: ignore
@@ -1714,6 +1762,7 @@ def sample(  # type: ignore[override]
         mode: str = "crossattn",
         verbose: bool = True,
         seg: torch.Tensor | None = None,
+        cfg: float | None = None,
     ) -> torch.Tensor | tuple[torch.Tensor, list[torch.Tensor]]:
         """
         Args:
@@ -1730,6 +1779,7 @@ def sample(  # type: ignore[override]
             verbose: if true, prints the progression bar of the sampling process.
             seg: if diffusion model is instance of SPADEDiffusionModel, or autoencoder_model
              is instance of SPADEAutoencoderKL, segmentation must be provided.
+            cfg: classifier-free-guidance scale, which indicates the level of strengthening on the conditioning.
         """
 
         if (
@@ -1757,6 +1807,7 @@ def sample(  # type: ignore[override]
             mode=mode,
             verbose=verbose,
             seg=seg,
+            cfg=cfg,
         )
 
         if save_intermediates:
diff --git a/tests/inferers/test_controlnet_inferers.py b/tests/inferers/test_controlnet_inferers.py
index 1ce81a71d5..2b6777a75f 100644
--- a/tests/inferers/test_controlnet_inferers.py
+++ b/tests/inferers/test_controlnet_inferers.py
@@ -482,16 +482,20 @@ def test_sample_intermediates(self, model_params, controlnet_params, input_shape
         scheduler = DDPMScheduler(num_train_timesteps=10)
         inferer = ControlNetDiffusionInferer(scheduler=scheduler)
         scheduler.set_timesteps(num_inference_steps=10)
-        sample, intermediates = inferer.sample(
-            input_noise=noise,
-            diffusion_model=model,
-            scheduler=scheduler,
-            controlnet=controlnet,
-            cn_cond=mask,
-            save_intermediates=True,
-            intermediate_steps=1,
-        )
-        self.assertEqual(len(intermediates), 10)
+
+        for cfg in [5, None]:
+            sample, intermediates = inferer.sample(
+                input_noise=noise,
+                diffusion_model=model,
+                scheduler=scheduler,
+                controlnet=controlnet,
+                cn_cond=mask,
+                save_intermediates=True,
+                intermediate_steps=1,
+                cfg=cfg,
+            )
+
+            self.assertEqual(len(intermediates), 10)
 
     @parameterized.expand(CNDM_TEST_CASES)
     @skipUnless(has_einops, "Requires einops")
diff --git a/tests/inferers/test_diffusion_inferer.py b/tests/inferers/test_diffusion_inferer.py
index 59b320d8a7..02890a71d4 100644
--- a/tests/inferers/test_diffusion_inferer.py
+++ b/tests/inferers/test_diffusion_inferer.py
@@ -88,6 +88,27 @@ def test_sample_intermediates(self, model_params, input_shape):
         )
         self.assertEqual(len(intermediates), 10)
 
+    @parameterized.expand(TEST_CASES)
+    @skipUnless(has_einops, "Requires einops")
+    def test_sample_cfg(self, model_params, input_shape):
+        model = DiffusionModelUNet(**model_params)
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        model.to(device)
+        model.eval()
+        noise = torch.randn(input_shape).to(device)
+        scheduler = DDPMScheduler(num_train_timesteps=10)
+        inferer = DiffusionInferer(scheduler=scheduler)
+        scheduler.set_timesteps(num_inference_steps=10)
+        sample, intermediates = inferer.sample(
+            input_noise=noise,
+            diffusion_model=model,
+            scheduler=scheduler,
+            save_intermediates=True,
+            intermediate_steps=1,
+            cfg=5,
+        )
+        self.assertEqual(sample.shape, noise.shape)
+
     @parameterized.expand(TEST_CASES)
     @skipUnless(has_einops, "Requires einops")
     def test_ddpm_sampler(self, model_params, input_shape):
@@ -244,6 +265,38 @@ def test_sampler_conditioned_concat(self, model_params, input_shape):
         )
         self.assertEqual(len(intermediates), 10)
 
+    @parameterized.expand(TEST_CASES)
+    @skipUnless(has_einops, "Requires einops")
+    def test_sampler_conditioned_concat_cfg(self, model_params, input_shape):
+        # copy the model_params dict to prevent from modifying test cases
+        model_params = model_params.copy()
+        n_concat_channel = 2
+        model_params["in_channels"] = model_params["in_channels"] + n_concat_channel
+        model_params["cross_attention_dim"] = None
+        model_params["with_conditioning"] = False
+        model = DiffusionModelUNet(**model_params)
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        model.to(device)
+        model.eval()
+        noise = torch.randn(input_shape).to(device)
+        conditioning_shape = list(input_shape)
+        conditioning_shape[1] = n_concat_channel
+        conditioning = torch.randn(conditioning_shape).to(device)
+        scheduler = DDIMScheduler(num_train_timesteps=1000)
+        inferer = DiffusionInferer(scheduler=scheduler)
+        scheduler.set_timesteps(num_inference_steps=10)
+        sample, intermediates = inferer.sample(
+            input_noise=noise,
+            diffusion_model=model,
+            scheduler=scheduler,
+            save_intermediates=True,
+            intermediate_steps=1,
+            conditioning=conditioning,
+            mode="concat",
+            cfg=5,
+        )
+        self.assertEqual(len(intermediates), 10)
+
     @parameterized.expand(TEST_CASES)
     @skipUnless(has_einops, "Requires einops")
     def test_sampler_conditioned_concat_rflow(self, model_params, input_shape):
diff --git a/tests/inferers/test_latent_diffusion_inferer.py b/tests/inferers/test_latent_diffusion_inferer.py
index c20cb5d6ff..ed5e1a149e 100644
--- a/tests/inferers/test_latent_diffusion_inferer.py
+++ b/tests/inferers/test_latent_diffusion_inferer.py
@@ -414,6 +414,55 @@ def test_sample_shape(
                 )
             self.assertEqual(sample.shape, input_shape)
 
+    @parameterized.expand(TEST_CASES)
+    @skipUnless(has_einops, "Requires einops")
+    def test_sample_shape_with_cfg(
+        self, ae_model_type, autoencoder_params, dm_model_type, stage_2_params, input_shape, latent_shape
+    ):
+        stage_1 = None
+
+        if ae_model_type == "AutoencoderKL":
+            stage_1 = AutoencoderKL(**autoencoder_params)
+        if ae_model_type == "VQVAE":
+            stage_1 = VQVAE(**autoencoder_params)
+        if dm_model_type == "SPADEDiffusionModelUNet":
+            stage_2 = SPADEDiffusionModelUNet(**stage_2_params)
+        else:
+            stage_2 = DiffusionModelUNet(**stage_2_params)
+
+        device = "cuda:0" if torch.cuda.is_available() else "cpu"
+        stage_1.to(device)
+        stage_2.to(device)
+        stage_1.eval()
+        stage_2.eval()
+
+        noise = torch.randn(latent_shape).to(device)
+
+        for scheduler in [DDPMScheduler(num_train_timesteps=10), RFlowScheduler(num_train_timesteps=1000)]:
+            inferer = LatentDiffusionInferer(scheduler=scheduler, scale_factor=1.0)
+            scheduler.set_timesteps(num_inference_steps=10)
+
+            if ae_model_type == "SPADEAutoencoderKL" or dm_model_type == "SPADEDiffusionModelUNet":
+                input_shape_seg = list(input_shape)
+                if "label_nc" in stage_2_params.keys():
+                    input_shape_seg[1] = stage_2_params["label_nc"]
+                else:
+                    input_shape_seg[1] = autoencoder_params["label_nc"]
+                input_seg = torch.randn(input_shape_seg).to(device)
+                sample = inferer.sample(
+                    input_noise=noise,
+                    autoencoder_model=stage_1,
+                    diffusion_model=stage_2,
+                    scheduler=scheduler,
+                    seg=input_seg,
+                    cfg=5,
+                )
+            else:
+                sample = inferer.sample(
+                    input_noise=noise, autoencoder_model=stage_1, diffusion_model=stage_2, scheduler=scheduler, cfg=5
+                )
+            self.assertEqual(sample.shape, input_shape)
+
     @parameterized.expand(TEST_CASES)
     @skipUnless(has_einops, "Requires einops")
     def test_sample_intermediates(