diff --git a/build-scripts/config_common.cmake b/build-scripts/config_common.cmake
index 8cdce4a017..c2121e424a 100644
--- a/build-scripts/config_common.cmake
+++ b/build-scripts/config_common.cmake
@@ -141,28 +141,58 @@ include (${WAMR_ROOT_DIR}/build-scripts/package.cmake)
 
 if (NOT DEFINED WAMR_BUILD_SANITIZER)
   set(WAMR_BUILD_SANITIZER $ENV{WAMR_BUILD_SANITIZER})
-endif ()
+endif()
 
-if (NOT DEFINED WAMR_BUILD_SANITIZER)
-  set(WAMR_BUILD_SANITIZER "")
-elseif (WAMR_BUILD_SANITIZER STREQUAL "ubsan")
-  set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -g -O0 -fno-omit-frame-pointer -fsanitize=undefined -fno-sanitize-recover=all -fno-sanitize=alignment" )
-  set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fsanitize=undefined")
-elseif (WAMR_BUILD_SANITIZER STREQUAL "asan")
-  if (NOT WAMR_BUILD_JIT EQUAL 1)
-    set (ASAN_OPTIONS "verbosity=2 debug=true ")
-    set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -g -O0 -fno-omit-frame-pointer -fsanitize=address -fno-sanitize-recover=all" )
-    set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fsanitize=address")
+if (NOT WAMR_BUILD_SANITIZER STREQUAL "")
+  set(SUPPORTED_SANITIZERS "ubsan;asan;tsan;posan")
+  string(REPLACE "," ";" SANITIZER_LIST "${WAMR_BUILD_SANITIZER}")
+
+  # Check uncompabile sanitizers
+  if("tsan" IN_LIST SANITIZER_LIST AND "asan" IN_LIST SANITIZER_LIST)
+    message(FATAL_ERROR "ThreadSanitizer (tsan) and AddressSanitizer (asan) cannot be used together!")
   endif()
-elseif (WAMR_BUILD_SANITIZER STREQUAL "tsan")
-  set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -g -O0 -fno-omit-frame-pointer -fsanitize=thread -fno-sanitize-recover=all" )
-  set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fsanitize=thread")
-elseif (WAMR_BUILD_SANITIZER STREQUAL "posan")
-  set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -g -O0 -fno-omit-frame-pointer -fsanitize=pointer-overflow -fno-sanitize-recover=all" )
-  set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fsanitize=pointer-overflow")
-elseif (NOT (WAMR_BUILD_SANITIZER STREQUAL "") )
-  message(SEND_ERROR "Unsupported sanitizer: ${WAMR_BUILD_SANITIZER}")
-endif()
+
+  # Check every sanitizer in the list
+  set(INVALID_SANITIZERS "")
+  list(REMOVE_DUPLICATES SANITIZER_LIST)
+  set(SANITIZER_FLAGS)
+  set(NO_SANITIZER_FLAGS)
+  foreach(sanitizer ${SANITIZER_LIST})
+    string(STRIP "${sanitizer}" sanitizer)
+    if(NOT sanitizer IN_LIST SUPPORTED_SANITIZERS)
+      list(APPEND INVALID_SANITIZERS "${sanitizer}")
+    elseif(sanitizer STREQUAL "ubsan")
+      list(APPEND SANITIZER_FLAGS "undefined")
+      list(APPEND NO_SANITIZER_FLAGS "alignment")
+    elseif(sanitizer STREQUAL "asan")
+      if (NOT WAMR_BUILD_JIT EQUAL 1)
+        set(ENV{ASAN_OPTIONS} "verbosity=2 debug=true")
+        list(APPEND SANITIZER_FLAGS "address")
+      else()
+        message(WARNING "AddressSanitizer is not supported in LLVM JIT mode, skip it")
+      endif()
+    elseif(sanitizer STREQUAL "tsan")
+      list(APPEND SANITIZER_FLAGS "thread")
+    elseif(sanitizer STREQUAL "posan")
+      list(APPEND SANITIZER_FLAGS "pointer-overflow")
+    endif()
+  endforeach()
+
+  if(INVALID_SANITIZERS)
+    message(FATAL_ERROR "Unsupported sanitizers: ${INVALID_SANITIZERS}")
+  endif()
+  # common flags for all sanitizers
+  set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -g -O0 -fno-omit-frame-pointer -fno-sanitize-recover=all")
+  if(SANITIZER_FLAGS)
+    string(REPLACE ";" "," SANITIZER_FLAGS_STR "${SANITIZER_FLAGS}")
+    set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fsanitize=${SANITIZER_FLAGS_STR}")
+    set(CMAKE_EXE_LINKER_FLAGS "${CMAKE_EXE_LINKER_FLAGS} -fsanitize=${SANITIZER_FLAGS_STR}")
+  endif()
+  if(NO_SANITIZER_FLAGS)
+    string(REPLACE ";" "," NO_SANITIZER_FLAGS_STR "${NO_SANITIZER_FLAGS}")
+    set(CMAKE_C_FLAGS "${CMAKE_C_FLAGS} -fno-sanitize=${NO_SANITIZER_FLAGS_STR}")
+  endif()
+endif ()
 
 if (WAMR_BUILD_LINUX_PERF EQUAL 1)
   if (NOT WAMR_BUILD_JIT AND NOT WAMR_BUILD_AOT)
diff --git a/tests/wamr-test-suites/test_wamr.sh b/tests/wamr-test-suites/test_wamr.sh
index 6f498653f0..1edf363bcb 100755
--- a/tests/wamr-test-suites/test_wamr.sh
+++ b/tests/wamr-test-suites/test_wamr.sh
@@ -39,7 +39,9 @@ function help()
     echo "-F set the firmware path used by qemu"
     echo "-C enable code coverage collect"
     echo "-j set the platform to test"
-    echo "-T set sanitizer to use in tests(ubsan|tsan|asan|posan)"
+    echo "-T set the sanitizer(s) used during testing. It can be either a comma-separated list 
+                                            (e.g., ubsan, asan) or a single option 
+                                            (e.g., ubsan, tsan, asan, posan)."
     echo "-A use the specified wamrc command instead of building it"
     echo "-N enable extended const expression feature"
     echo "-r [requirement name] [N [N ...]] specify a requirement name followed by one or more"
@@ -1066,26 +1068,9 @@ function trigger()
         EXTRA_COMPILE_FLAGS+=" -DWAMR_BUILD_TAIL_CALL=1"
     fi
 
-    echo "SANITIZER IS" $WAMR_BUILD_SANITIZER
-
-    if [[ "$WAMR_BUILD_SANITIZER" == "ubsan" ]]; then
-        echo "Setting run with ubsan"
-        EXTRA_COMPILE_FLAGS+=" -DWAMR_BUILD_SANITIZER=ubsan"
-    fi
-
-    if [[ "$WAMR_BUILD_SANITIZER" == "asan" ]]; then
-        echo "Setting run with asan"
-        EXTRA_COMPILE_FLAGS+=" -DWAMR_BUILD_SANITIZER=asan"
-    fi
-
-    if [[ "$WAMR_BUILD_SANITIZER" == "tsan" ]]; then
-        echo "Setting run with tsan"
-        EXTRA_COMPILE_FLAGS+=" -DWAMR_BUILD_SANITIZER=tsan"
-    fi
-
-    if [[ "$WAMR_BUILD_SANITIZER" == "posan" ]]; then
-        echo "Setting run with posan"
-        EXTRA_COMPILE_FLAGS+=" -DWAMR_BUILD_SANITIZER=posan"
+    if [[ -n "$WAMR_BUILD_SANITIZER" ]]; then
+        echo "Setting run with sanitizer(s): $WAMR_BUILD_SANITIZER"
+        EXTRA_COMPILE_FLAGS+=" -DWAMR_BUILD_SANITIZER=$WAMR_BUILD_SANITIZER"
     fi
 
     # Make sure we're using the builtin WASI libc implementation