diff --git a/mantle/kola/tests/misc/multipath.go b/mantle/kola/tests/misc/multipath.go
index dcc00f9c3d..bdd0b1d56d 100644
--- a/mantle/kola/tests/misc/multipath.go
+++ b/mantle/kola/tests/misc/multipath.go
@@ -16,6 +16,7 @@ package misc
 
 import (
 	"fmt"
+	"strconv"
 	"strings"
 	"time"
 
@@ -103,6 +104,13 @@ systemd:
 
         [Install]
         WantedBy=multi-user.target`)
+
+	mpath_single_disk = conf.Butane(`
+variant: fcos
+version: 1.6.0
+kernel_arguments:
+  should_exist:
+    - rd.multipath=default`)
 )
 
 func init() {
@@ -132,6 +140,16 @@ func init() {
 		UserData:        mpath_on_var_lib_containers,
 		AdditionalDisks: []string{"1G:mpath,wwn=1"},
 	})
+	// See https://issues.redhat.com/browse/OCPBUGS-56597
+	register.RegisterTest(&register.Test{
+		Name:          "multipath.single-disk",
+		Description:   "Verify that multipath can be reduced to one path",
+		Run:           runMultipathReduceDisk,
+		ClusterSize:   1,
+		Platforms:     []string{"qemu"},
+		UserData:      mpath_single_disk,
+		MultiPathDisk: true,
+	})
 }
 
 func verifyMultipathBoot(c cluster.TestCluster, m platform.Machine) {
@@ -223,3 +241,37 @@ func waitForCompleteFirstboot(c cluster.TestCluster) {
 		c.Fatalf("Timed out while waiting for first-boot-complete.target to be ready: %v", err)
 	}
 }
+
+func verifyMultipathDisks(c cluster.TestCluster, m platform.Machine, expect int) {
+	device := strings.TrimSpace(string(c.MustSSH(m, "sudo multipath -l -v 1")))
+	if device == "" {
+		c.Fatalf("Failed to find multipath device")
+	}
+	output := string(c.MustSSHf(m, "lsblk --pairs --paths --inverse --output NAME /dev/mapper/%s | grep -v /dev/mapper | wc -l", device))
+	count, err := strconv.Atoi(strings.TrimSpace(output))
+	if err != nil {
+		c.Fatalf("Failed to parse device count: %v", err)
+	}
+
+	if count != expect {
+		c.Fatalf("Expected %d multipath devices, but found %d", expect, count)
+	}
+}
+
+func runMultipathReduceDisk(c cluster.TestCluster) {
+	m := c.Machines()[0]
+	verifyMultipathBoot(c, m)
+	// wait until first-boot-complete.target is reached
+	waitForCompleteFirstboot(c)
+	verifyMultipathDisks(c, m, 2)
+
+	if err := m.(platform.QEMUMachine).RemoveBlockDeviceForMultipath("mpath11"); err != nil {
+		c.Fatalf("Failed to remove multipath disk: %v", err)
+	}
+
+	if err := m.Reboot(); err != nil {
+		c.Fatalf("Failed to reboot the machine: %v", err)
+	}
+	verifyMultipathDisks(c, m, 1)
+	c.RunCmdSync(m, "grep mpath.wwid= /proc/cmdline")
+}
diff --git a/mantle/platform/machine/qemu/machine.go b/mantle/platform/machine/qemu/machine.go
index 9ecfc62651..e567690018 100644
--- a/mantle/platform/machine/qemu/machine.go
+++ b/mantle/platform/machine/qemu/machine.go
@@ -124,3 +124,7 @@ func (m *machine) JournalOutput() string {
 func (m *machine) RemovePrimaryBlockDevice() error {
 	return m.inst.RemovePrimaryBlockDevice()
 }
+
+func (m *machine) RemoveBlockDeviceForMultipath(device string) error {
+	return m.inst.RemoveBlockDeviceForMultipath(device)
+}
diff --git a/mantle/platform/qemu.go b/mantle/platform/qemu.go
index c236601f30..7201de6c94 100644
--- a/mantle/platform/qemu.go
+++ b/mantle/platform/qemu.go
@@ -85,6 +85,8 @@ type QEMUMachine interface {
 	// RemovePrimaryBlockDevice removes the primary device from a given qemu
 	// instance and sets the secondary device as primary.
 	RemovePrimaryBlockDevice() error
+	// RemoveBlockDeviceForMultipath removes the specified device on multipath.
+	RemoveBlockDeviceForMultipath(device string) error
 }
 
 // Disk holds the details of a virtual disk.
@@ -445,6 +447,30 @@ func (inst *QemuInstance) RemovePrimaryBlockDevice() (err2 error) {
 	return nil
 }
 
+// RemoveBlockDeviceForMultipath remove the specified device on multipath.
+func (inst *QemuInstance) RemoveBlockDeviceForMultipath(device string) error {
+	blkdevs, err := inst.listBlkDevices()
+	if err != nil {
+		return errors.Wrapf(err, "Could not list block devices through qmp")
+	}
+
+	var devicePath string
+	for _, dev := range blkdevs.Return {
+		if dev.Device == device {
+			devicePath = dev.DevicePath
+			break
+		}
+	}
+	if devicePath == "" {
+		return fmt.Errorf("Target device %q not found in block device list", device)
+	}
+
+	if err = inst.deleteBlockDevice(devicePath); err != nil {
+		return errors.Wrapf(err, "Could not delete device %v", devicePath)
+	}
+	return nil
+}
+
 // A directory mounted from the host into the guest, via 9p or virtiofs
 type HostMount struct {
 	src      string