diff --git a/sycl/test-e2e/AddressSanitizer/lit.local.cfg b/sycl/test-e2e/AddressSanitizer/lit.local.cfg
index 2c460b824422d..46e3e7fe9bf1e 100644
--- a/sycl/test-e2e/AddressSanitizer/lit.local.cfg
+++ b/sycl/test-e2e/AddressSanitizer/lit.local.cfg
@@ -31,4 +31,7 @@ unsupported_san_flags = [
 if any(flag in config.cxx_flags for flag in unsupported_san_flags):
     config.unsupported=True
 
-config.environment["ZE_AFFINITY_MASK"] = "0"
+if hasattr(config, 'ze_affinity_mask') and config.ze_affinity_mask is not None:
+    config.environment["ZE_AFFINITY_MASK"] = config.ze_affinity_mask
+else:
+    config.environment["ZE_AFFINITY_MASK"] = "0"
diff --git a/sycl/test-e2e/MemorySanitizer/lit.local.cfg b/sycl/test-e2e/MemorySanitizer/lit.local.cfg
index 8b643a2c4abbc..0af20d640d932 100644
--- a/sycl/test-e2e/MemorySanitizer/lit.local.cfg
+++ b/sycl/test-e2e/MemorySanitizer/lit.local.cfg
@@ -39,4 +39,7 @@ unsupported_san_flags = [
 if any(flag in config.cxx_flags for flag in unsupported_san_flags):
     config.unsupported=True
 
-config.environment["ZE_AFFINITY_MASK"] = "0"
+if hasattr(config, 'ze_affinity_mask') and config.ze_affinity_mask is not None:
+    config.environment["ZE_AFFINITY_MASK"] = config.ze_affinity_mask
+else:
+    config.environment["ZE_AFFINITY_MASK"] = "0"
diff --git a/sycl/test-e2e/ThreadSanitizer/lit.local.cfg b/sycl/test-e2e/ThreadSanitizer/lit.local.cfg
index 63a387034a132..a4500c5d13153 100644
--- a/sycl/test-e2e/ThreadSanitizer/lit.local.cfg
+++ b/sycl/test-e2e/ThreadSanitizer/lit.local.cfg
@@ -34,4 +34,7 @@ unsupported_san_flags = [
 if any(flag in config.cxx_flags for flag in unsupported_san_flags):
     config.unsupported=True
 
-config.environment["ZE_AFFINITY_MASK"] = "0"
+if hasattr(config, 'ze_affinity_mask') and config.ze_affinity_mask is not None:
+    config.environment["ZE_AFFINITY_MASK"] = config.ze_affinity_mask
+else:
+    config.environment["ZE_AFFINITY_MASK"] = "0"
diff --git a/sycl/test-e2e/format.py b/sycl/test-e2e/format.py
index b503108f937b1..2cb52e6bd5469 100644
--- a/sycl/test-e2e/format.py
+++ b/sycl/test-e2e/format.py
@@ -283,6 +283,15 @@ def get_extra_env(sycl_devices):
             # so that device might still be accessible to some of the tests yet
             # we won't set the environment variable below for such scenario.
             extra_env = []
+
+            # Include ZE_AFFINITY_MASK if set by lit.local.cfg (e.g., for sanitizer tests)
+            if "ZE_AFFINITY_MASK" in test.config.environment:
+                extra_env.append(
+                    "ZE_AFFINITY_MASK={}".format(
+                        test.config.environment["ZE_AFFINITY_MASK"]
+                    )
+                )
+
             if "level_zero:gpu" in sycl_devices and litConfig.params.get("ur_l0_debug"):
                 extra_env.append("UR_L0_DEBUG={}".format(test.config.ur_l0_debug))
 
@@ -342,8 +351,14 @@ def get_extra_env(sycl_devices):
                 elif "level_zero_v1" in full_dev_name:
                     expanded += " env UR_LOADER_USE_LEVEL_ZERO_V2=0"
 
+                # If ZE_AFFINITY_MASK is set, it filters devices so we should use :0
+                device_selector = parsed_dev_name
+                if "ZE_AFFINITY_MASK" in test.config.environment:
+                    backend, _ = parsed_dev_name.split(":", 1)
+                    device_selector = f"{backend}:0"
+
                 expanded += " ONEAPI_DEVICE_SELECTOR={} {}".format(
-                    parsed_dev_name, test.config.run_launcher
+                    device_selector, test.config.run_launcher
                 )
                 cmd = directive.command.replace("%{run}", expanded)
                 # Expand device-specific condtions (%if ... %{ ... %}).
diff --git a/sycl/test-e2e/lit.cfg.py b/sycl/test-e2e/lit.cfg.py
index d39cd7134e603..9f271aae2d9cd 100644
--- a/sycl/test-e2e/lit.cfg.py
+++ b/sycl/test-e2e/lit.cfg.py
@@ -9,9 +9,6 @@
 import shlex
 import shutil
 
-import lit.formats
-import lit.util
-
 from lit.llvm import llvm_config
 from lit.llvm.subst import ToolSubst, FindTool
 
@@ -917,12 +914,14 @@ def get_sycl_ls_verbose(sycl_device, env):
 
     env = copy.copy(llvm_config.config.environment)
 
+    backend_for_selector = backend.replace("_v2", "").replace("_v1", "")
+
     # Find all available devices under the backend
-    env["ONEAPI_DEVICE_SELECTOR"] = backend + ":*"
+    env["ONEAPI_DEVICE_SELECTOR"] = backend_for_selector + ":*"
 
     detected_architectures = []
 
-    platform_devices = remove_level_zero_suffix(backend + ":*")
+    platform_devices = backend_for_selector + ":*"
 
     for line in get_sycl_ls_verbose(platform_devices, env).stdout.splitlines():
         if re.match(r" *Architecture:", line):
@@ -948,6 +947,16 @@ def get_sycl_ls_verbose(sycl_device, env):
 
 config.sycl_devices = filtered_sycl_devices
 
+# Determine ZE_AFFINITY_MASK for Level Zero devices.
+# Sanitizer tests need to set ZE_AFFINITY_MASK to a single device index
+config.ze_affinity_mask = None
+for sycl_device in remove_level_zero_suffix(config.sycl_devices):
+    be, dev = sycl_device.split(":")
+    if be == "level_zero" and dev.isdigit():
+        if config.ze_affinity_mask is None:
+            config.ze_affinity_mask = dev
+            break
+
 for sycl_device in remove_level_zero_suffix(config.sycl_devices):
     be, dev = sycl_device.split(":")
     config.available_features.add("any-device-is-" + dev)
@@ -1112,6 +1121,7 @@ def get_sycl_ls_verbose(sycl_device, env):
     features.update(sg_size_features)
     features.update(architecture_feature)
     features.update(device_family)
+    features.update(aspects)
 
     be, dev = sycl_device.split(":")
     features.add(dev.replace("fpga", "accelerator"))