diff --git a/README.md b/README.md
index 3599bb1..1cad334 100644
--- a/README.md
+++ b/README.md
@@ -95,6 +95,15 @@ def row_by_value(df, col, value):
     """Slice out row from DataFrame by a value."""
     return df[df[col] == value].squeeze()
 
+# register_series_and_dataframe_method can optionally include arguments to pass to pd.DataFrame.apply()
+#
+# Note that this is not the best example as total_diff can be vectorized instead of using 
+# pd.DataFrame.apply() with register_series_and_dataframe_method
+@pf.register_series_and_dataframe_method(axis=1)
+def total_diff(col, start_idx=0, end_idx=-1):
+  """ Return difference between the last and the first values per row/column"""
+  return col.iloc[end_idx] - col.iloc[start_idx]
+
 ```
 
 ```python
@@ -120,14 +129,30 @@ df.row_by_value('x', 10)
 # x    10
 # y     0
 # Name: 0, dtype: int64
+
+df2.total_diff()
+
+# 0   -10
+# 1   -18
+# 2   -20
+# dtype: int64
+
+# It is possible to override the decorator kwargs from the function call
+df.total_diff(axis=0, end_idx=-2)
+
+# x    10
+# y     2
+# dtype: int64
+
 ```
 
 ## Available Methods
 
 - **register_dataframe_method**: register a method directly with a pandas DataFrame.
 - **register_dataframe_accessor**: register an accessor (and it's methods) with a pandas DataFrame.
-- **register_series_method**: register a methods directly with a pandas Series.
+- **register_series_method**: register a method directly with a pandas Series.
 - **register_series_accessor**: register an accessor (and it's methods) with a pandas Series.
+- **register_series_and_dataframe_method**: register a method directly with both pandas Series and DataFrames. Please note that this will use pd.DataFrame.apply on dataframes which can result in a loss in performance. Vectorized operations should always be preferred.
 
 ## Installation
 
diff --git a/pandas_flavor/__init__.py b/pandas_flavor/__init__.py
index 80755f9..c855523 100644
--- a/pandas_flavor/__init__.py
+++ b/pandas_flavor/__init__.py
@@ -1,7 +1,8 @@
 from .register import (register_series_method,
                        register_series_accessor,
                        register_dataframe_method,
-                       register_dataframe_accessor)
+                       register_dataframe_accessor,
+                       register_series_and_dataframe_method)
 from .xarray import (register_xarray_dataarray_method, 
                      register_xarray_dataset_method)
 
diff --git a/pandas_flavor/register.py b/pandas_flavor/register.py
index d8c20e7..ce1e17f 100644
--- a/pandas_flavor/register.py
+++ b/pandas_flavor/register.py
@@ -1,6 +1,7 @@
 from functools import wraps
 from .pandas_internals import (register_series_accessor,
                               register_dataframe_accessor)
+from pandas.core.frame import DataFrame
 
 
 def register_dataframe_method(method):
@@ -39,7 +40,6 @@ def register_series_method(method):
     """Register a function as a method attached to the Pandas Series.
     """
     def inner(*args, **kwargs):
-
         class AccessorMethod(object):
             __doc__ = method.__doc__
 
@@ -55,3 +55,57 @@ def __call__(self, *args, **kwargs):
         return method
 
     return inner()
+
+
+def register_series_and_dataframe_method(_func=None, **decorator_kwargs):
+    """Register a function as a method attached to the Pandas Series or DataFrame
+    Method should be written as a function to apply on each column or each row
+
+    Can optionally include arguments to pass to pd.DataFrame.apply() such as axis=1
+
+    Please note that if the operation can be vectorized, register_dataframe_method will
+    likely yield higher performance as this decorator will always use pd.DataFrame.apply()
+
+    Example
+    -------
+
+    .. code-block:: python
+
+        @register_series_method
+        def total_pct_change(df):
+            return (df.iloc[-1] - df.iloc[0]) / df.iloc[0]
+    """
+    def inner_wrapper(method):
+        def inner(*args, **kwargs):
+            class SerAccessorMethod(object):
+                __doc__ = method.__doc__
+
+                def __init__(self, pandas_obj):
+                    self._obj = pandas_obj
+
+                @wraps(method)
+                def __call__(self, *args, **kwargs):
+                    return method(self._obj, *args, **kwargs)
+
+            class DFAccessorMethod(object):
+                __doc__ = method.__doc__
+
+                def __init__(self, pandas_obj):
+                    self._obj = pandas_obj
+
+                @wraps(method)
+                def __call__(self, *args, **kwargs):
+                    kwargs = {**decorator_kwargs, **kwargs}
+                    return DataFrame.apply(self._obj, method, args=args, **kwargs)
+
+            register_series_accessor(method.__name__)(SerAccessorMethod)
+            register_dataframe_accessor(method.__name__)(DFAccessorMethod)
+
+            return method
+
+        return inner()
+
+    if _func is None:
+        return inner_wrapper
+    else:
+        return inner_wrapper(_func)
\ No newline at end of file