diff --git a/pyodide_build/_f2c_fixes.py b/pyodide_build/_f2c_fixes.py
index d66ef823..de5ba4af 100644
--- a/pyodide_build/_f2c_fixes.py
+++ b/pyodide_build/_f2c_fixes.py
@@ -76,6 +76,15 @@ def scipy_fix_cfile(path: Path) -> None:
     text = text.replace("void(*)", "int(*)")
     text = text.replace("static void f2py_setup_", "static int f2py_setup_")
 
+    # Fix Cython-generated function pointer casts for __Pyx_IsSameCFunction
+    # for _matfuncs_sqrtm for builds of SciPy 1.16.0.
+    # TODO: I'm not sure if this is the best place to put this, but it works
+    text = re.sub(
+        r"(__Pyx_IsSameCFunction\([^,]+,\s*)\(int\(\*\)\(void\)\)",
+        r"\1(void(*)(void))",
+        text,
+    )
+
     if path.name.endswith("_flapackmodule.c"):
         text = text.replace(",size_t", "")
         text = re.sub(r",slen\([a-z]*\)\)", ")", text)