diff --git a/src/pip/_internal/exceptions.py b/src/pip/_internal/exceptions.py
index d6e9095fb55..a22e0c0aa33 100644
--- a/src/pip/_internal/exceptions.py
+++ b/src/pip/_internal/exceptions.py
@@ -31,6 +31,7 @@
 
     from pip._internal.metadata import BaseDistribution
     from pip._internal.network.download import _FileDownload
+    from pip._internal.network.rfc9457 import ProblemDetails
     from pip._internal.req.req_install import InstallRequirement
 
 logger = logging.getLogger(__name__)
@@ -335,6 +336,30 @@ def __str__(self) -> str:
         return str(self.error_msg)
 
 
+class HTTPProblemDetailsError(NetworkConnectionError):
+    """HTTP error with RFC 9457 Problem Details."""
+
+    def __init__(
+        self,
+        problem_details: ProblemDetails,
+        response: Response,
+    ) -> None:
+        """
+        Initialize HTTPProblemDetailsError with problem details.
+
+        Args:
+            problem_details: Parsed RFC 9457 problem details
+            response: The HTTP response object
+        """
+        self.problem_details = problem_details
+        error_msg = str(problem_details)
+
+        super().__init__(
+            error_msg=error_msg,
+            response=response,
+        )
+
+
 class InvalidWheelFilename(InstallationError):
     """Invalid wheel filename."""
 
diff --git a/src/pip/_internal/network/rfc9457.py b/src/pip/_internal/network/rfc9457.py
new file mode 100644
index 00000000000..7ec38031cb9
--- /dev/null
+++ b/src/pip/_internal/network/rfc9457.py
@@ -0,0 +1,91 @@
+"""RFC 9457 - Problem Details for HTTP APIs
+
+This module provides support for RFC 9457 (Problem Details for HTTP APIs),
+a standardized format for describing errors in HTTP APIs.
+
+Reference: https://www.rfc-editor.org/rfc/rfc9457
+"""
+
+from __future__ import annotations
+
+import json
+import logging
+from dataclasses import dataclass
+from typing import Any
+
+from pip._vendor.requests.models import Response
+
+logger = logging.getLogger(__name__)
+
+RFC9457_CONTENT_TYPE = "application/problem+json"
+
+
+@dataclass
+class ProblemDetails:
+    """Represents an RFC 9457 Problem Details object.
+
+    This class encapsulates the core fields defined in RFC 9457:
+    - status: The HTTP status code
+    - title: A short, human-readable summary of the problem type
+    - detail: A human-readable explanation specific to this occurrence
+    """
+
+    status: int | None = None
+    title: str | None = None
+    detail: str | None = None
+
+    @classmethod
+    def from_dict(cls, data: dict[str, Any]) -> ProblemDetails:
+        return cls(
+            status=data.get("status"),
+            title=data.get("title"),
+            detail=data.get("detail"),
+        )
+
+    @classmethod
+    def from_json(cls, json_str: str) -> ProblemDetails:
+        data = json.loads(json_str)
+        if not isinstance(data, dict):
+            raise ValueError("Problem details JSON must be an object")
+        return cls.from_dict(data)
+
+    def __str__(self) -> str:
+        parts = []
+
+        if self.title:
+            parts.append(f"{self.title}")
+        if self.status:
+            parts.append(f"(Status: {self.status})")
+        if self.detail:
+            parts.append(f"\n{self.detail}")
+
+        return " ".join(parts) if parts else "Unknown problem"
+
+
+def is_problem_details_response(response: Response) -> bool:
+    content_type = response.headers.get("Content-Type", "")
+    return content_type.startswith(RFC9457_CONTENT_TYPE)
+
+
+def parse_problem_details(response: Response) -> ProblemDetails | None:
+    if not is_problem_details_response(response):
+        return None
+
+    try:
+        body = response.content
+        if not body:
+            logger.warning("Problem details response has empty body")
+            return None
+
+        problem = ProblemDetails.from_json(body.decode("utf-8"))
+
+        if problem.status is None:
+            problem.status = response.status_code
+
+        logger.debug(
+            "Parsed problem details: status=%s, title=%s", problem.status, problem.title
+        )
+        return problem
+
+    except (json.JSONDecodeError, ValueError):
+        return None
diff --git a/src/pip/_internal/network/utils.py b/src/pip/_internal/network/utils.py
index 74d3111cff0..e6702d94f7c 100644
--- a/src/pip/_internal/network/utils.py
+++ b/src/pip/_internal/network/utils.py
@@ -2,7 +2,8 @@
 
 from pip._vendor.requests.models import Response
 
-from pip._internal.exceptions import NetworkConnectionError
+from pip._internal.exceptions import HTTPProblemDetailsError, NetworkConnectionError
+from pip._internal.network.rfc9457 import parse_problem_details
 
 # The following comments and HTTP headers were originally added by
 # Donald Stufft in git commit 22c562429a61bb77172039e480873fb239dd8c03.
@@ -29,6 +30,14 @@
 
 
 def raise_for_status(resp: Response) -> None:
+    problem_details = parse_problem_details(resp)
+    if problem_details:
+        raise HTTPProblemDetailsError(
+            problem_details=problem_details,
+            response=resp,
+        )
+
+    # Fallback to standard error handling for non-RFC 9457 responses
     http_error_msg = ""
     if isinstance(resp.reason, bytes):
         # We attempt to decode utf-8 first because some servers
diff --git a/tests/unit/test_network_rfc9457.py b/tests/unit/test_network_rfc9457.py
new file mode 100644
index 00000000000..627d36112b8
--- /dev/null
+++ b/tests/unit/test_network_rfc9457.py
@@ -0,0 +1,169 @@
+"""Tests for RFC 9457 (Problem Details for HTTP APIs) support."""
+
+import json
+
+import pytest
+
+from pip._internal.exceptions import HTTPProblemDetailsError, NetworkConnectionError
+from pip._internal.network.rfc9457 import (
+    ProblemDetails,
+    is_problem_details_response,
+    parse_problem_details,
+)
+from pip._internal.network.utils import raise_for_status
+
+from tests.lib.requests_mocks import MockResponse
+
+
+class TestProblemDetails:
+    def test_from_dict(self) -> None:
+        data = {
+            "status": 404,
+            "title": "Not Found",
+            "detail": "Resource not found",
+        }
+
+        problem = ProblemDetails.from_dict(data)
+        assert problem.status == 404
+        assert problem.title == "Not Found"
+        assert problem.detail == "Resource not found"
+
+    def test_from_json(self) -> None:
+        json_str = json.dumps(
+            {
+                "status": 404,
+                "title": "Not Found",
+                "detail": "Resource not found",
+            }
+        )
+
+        problem = ProblemDetails.from_json(json_str)
+        assert problem.status == 404
+        assert problem.title == "Not Found"
+
+    def test_string_representation(self) -> None:
+        """Test string representation of ProblemDetails."""
+        problem = ProblemDetails(
+            status=403,
+            title="Access Denied",
+            detail="Your API token does not have permission",
+        )
+
+        str_repr = str(problem)
+        assert "Access Denied" in str_repr
+        assert "403" in str_repr
+        assert "API token" in str_repr
+
+
+class TestIsProblemDetailsResponse:
+    def test_detects_problem_json_content_type(self) -> None:
+        resp = MockResponse(b"")
+        resp.headers = {"Content-Type": "application/problem+json"}
+
+        assert is_problem_details_response(resp) is True
+
+    def test_detects_problem_json_with_charset(self) -> None:
+        resp = MockResponse(b"")
+        resp.headers = {"Content-Type": "application/problem+json; charset=utf-8"}
+
+        assert is_problem_details_response(resp) is True
+
+    def test_does_not_detect_regular_json(self) -> None:
+        resp = MockResponse(b"")
+        resp.headers = {"Content-Type": "application/json"}
+
+        assert is_problem_details_response(resp) is False
+
+    def test_does_not_detect_without_content_type(self) -> None:
+        resp = MockResponse(b"")
+        resp.headers = {}
+
+        assert is_problem_details_response(resp) is False
+
+
+class TestParseProblemDetails:
+    def test_parses_valid_problem_details(self) -> None:
+        problem_data = {
+            "status": 404,
+            "title": "Not Found",
+            "detail": "The package 'test-package' was not found",
+        }
+        resp = MockResponse(json.dumps(problem_data).encode())
+        resp.headers = {"Content-Type": "application/problem+json"}
+        resp.status_code = 404
+
+        problem = parse_problem_details(resp)
+        assert problem is not None
+        assert problem.status == 404
+        assert problem.title == "Not Found"
+        assert problem.detail is not None
+        assert "test-package" in problem.detail
+
+    def test_returns_none_for_non_problem_details(self) -> None:
+        resp = MockResponse(b"<html>Error</html>")
+        resp.headers = {"Content-Type": "text/html"}
+
+        problem = parse_problem_details(resp)
+        assert problem is None
+
+    def test_handles_malformed_json(self) -> None:
+        resp = MockResponse(b"not valid json")
+        resp.headers = {"Content-Type": "application/problem+json"}
+
+        problem = parse_problem_details(resp)
+        assert problem is None
+
+
+@pytest.mark.parametrize(
+    "status_code, title, detail",
+    [
+        (404, "Package Not Found", "The requested package does not exist"),
+        (500, "Internal Server Error", "An unexpected error occurred"),
+        (403, "Forbidden", "Access denied to this resource"),
+    ],
+)
+class TestRaiseForStatusWithProblemDetails:
+    def test_raises_http_problem_details_error(
+        self, status_code: int, title: str, detail: str
+    ) -> None:
+        problem_data = {
+            "status": status_code,
+            "title": title,
+            "detail": detail,
+        }
+        resp = MockResponse(json.dumps(problem_data).encode())
+        resp.status_code = status_code
+        resp.headers = {"Content-Type": "application/problem+json"}
+        resp.url = "https://pypi.org/simple/some-package/"
+
+        with pytest.raises(HTTPProblemDetailsError) as excinfo:
+            raise_for_status(resp)
+
+        assert excinfo.value.problem_details.status == status_code
+        assert excinfo.value.problem_details.title == title
+        assert excinfo.value.response == resp
+
+
+@pytest.mark.parametrize(
+    "status_code, error_type",
+    [
+        (404, "Client Error"),
+        (500, "Server Error"),
+        (403, "Client Error"),
+    ],
+)
+class TestRaiseForStatusBackwardCompatibility:
+    def test_raises_network_connection_error(
+        self, status_code: int, error_type: str
+    ) -> None:
+        resp = MockResponse(b"<html>Error</html>")
+        resp.status_code = status_code
+        resp.headers = {"Content-Type": "text/html"}
+        resp.url = "https://pypi.org/simple/nonexistent-package/"
+        resp.reason = "Error"
+
+        with pytest.raises(NetworkConnectionError) as excinfo:
+            raise_for_status(resp)
+
+        assert f"{status_code} {error_type}" in str(excinfo.value)
+        assert excinfo.value.response == resp