#2 DestVI tutorial is not running

[lordy5]

I get an AttributeError when calling explore_gamma_space caused by the fact that the code uses append on a dataframe, which is no longer supported. I think this is caused by scvi version 1.3.0 using a newer pandas version.

destvi_utils.explore_gamma_space(st_model, sc_model, ct_list=ct_list, ct_thresholds=ct_thresholds)

---------------------------------------------------------------------------
AttributeError                            Traceback (most recent call last)
[<ipython-input-30-ceebccb51f08>](https://localhost:8080/#) in <cell line: 0>()
----> 1 destvi_utils.explore_gamma_space(st_model, sc_model, ct_list=ct_list, ct_thresholds=ct_thresholds)

3 frames
[/usr/local/lib/python3.11/dist-packages/destvi_utils/_destvi_utils.py](https://localhost:8080/#) in explore_gamma_space(st_model, sc_model, st_adata, ct_thresholds, output_file, ct_list, key_proportions, key_spatial)
    338                     ranking = ranking[::-1]
    339                 gl = list(st_adata.var.index[ranking[:50]])
--> 340                 enr = gseapy.enrichr(
    341                     gene_list=gl,
    342                     description="pathway",

[/usr/local/lib/python3.11/dist-packages/gseapy/enrichr.py](https://localhost:8080/#) in enrichr(gene_list, gene_sets, organism, description, outdir, background, cutoff, format, figsize, top_term, no_plot, verbose)
    476     enr = Enrichr(gene_list, gene_sets, organism, description, outdir,
    477                   cutoff, background, format, figsize, top_term, no_plot, verbose)
--> 478     enr.run()
    479 
    480     return enr

[/usr/local/lib/python3.11/dist-packages/gseapy/enrichr.py](https://localhost:8080/#) in run(self)
    385             res.insert(0, "Gene_set", self._gs)
    386             # Append to master dataframe
--> 387             self.results = self.results.append(res, ignore_index=True)
    388             self.res2d = res
    389             if self._outdir is None: continue

[/usr/local/lib/python3.11/dist-packages/pandas/core/generic.py](https://localhost:8080/#) in __getattr__(self, name)
   6297         ):
   6298             return self[name]
-> 6299         return object.__getattribute__(self, name)
   6300 
   6301     @final

AttributeError: 'DataFrame' object has no attribute 'append'

Versions:

1.3.0

[ori-kron-wis]

Not related to scvi-version, as this point in tutorials fails for long time and relates to a fix needed in https://github.com/YosefLab/destvi_utils (possibly to package updates and CI/CD).
We can put this part of tutorial under comment for now